Study	Reason for exclusion
Albreski 1999	Study compares itraconazole to 'palliative care': trimming, soaking and cleaning. No placebo group
Alpsoy 1996	This is a dose‐finding study with no comparisons between different drugs or between drug and placebo
Avner 2006a	This is a dose‐finding study with no comparisons between different drugs or between drug and placebo
Avner 2006b	This is a dose‐finding study with no comparisons between different drugs or between drug and placebo
Chen 1999	This is a dose‐finding study with no comparisons between different drugs or between drug and placebo
De Cuyper 1996	This is a dose‐finding study with no comparisons between different drugs or between drug and placebo
De Doncker 1996	This is a dose‐finding study with no comparisons between different drugs or between drug and placebo
Faergemann 1996	Pharmacokinetic study of drug concentrations in healthy nails
Finlay 1994	Dose‐finding with no comparison between different drugs or a placebo. Also, focuses on pharmacokinetics and nail plate concentrations of drug (not clinical or mycological cure)
Gomez 1996	Looked at tinea pedis
Goodfield 1990	Not an RCT: no comparison group, only a treatment group
Havu 1997	This is a dose‐finding study (continuous vs pulse) with no comparisons between different drugs or between drug and placebo
Havu 1999	This is a dose‐finding study (continuous vs pulse) with no comparisons between different drugs or between drug and placebo
Hay 1987	Looked at efficacy of topical adjunct to griseofulvin
Maleszka 2001	Study assesses efficacy of adjuncts (amorolfine and pentoxifylline) to itraconazole and does not compare 2 different anti‐fungal agents
Pollak 2001	Dose finding for terbinafine, no placebo group
Safer 2000	Letter to the editor, not an RCT
Schatz 1995	Dose finding for terbinafine, no placebo group
Shemer 1999	This is a dose‐finding study for itraconazole with no comparisons between different drugs or between drug and placebo
Sommer 2003	Dose finding for terbinafine, no placebo group
Tausch 1997	Dose finding for terbinafine, no placebo group
van der Schroeff 1992	Dose finding for terbinafine, no placebo group
Warshaw 2001	This is a dose‐finding study for terbinafine (continuous vs intermittent) with no placebo group
Warshaw 2005	Dose finding (continuous vs pulse) for terbinafine, no placebo group
Watanabe 2004	This is a dose‐finding study for itraconazole pulse therapy
Yadav 2015	Dose finding for terbinafine, no placebo group
Zaias 1983	Fungal skin infections, not nail infections

RCT: randomised controlled trial.