Battaglia 1999

Methods	Randomised controlled trial
Participants	Women attending fertility clinic having failed an IVF cycle (poor responders) (n = 34). Mean age: 40 ± 2.1 years, range 37 ‐ 44 years. Undergoing IVF Inclusion: Infertile women with tubal infertility who had not taken hormonal treatments 4 months prior to 1st IVF treatment Exclusion: Intercurrent illness, BMI > 30, endometriosis, ovarian functional cyst or ovariectomy, regular exercise, heavy smokers (> 10 a day), diastolic blood pressure > 90 mmHg
Interventions	1. Oral L arginine 16 g: 1 tablet a day (n = 17) 2. No treatment (n = 17) Duration: from day 1 of the menstrual cycle to end of the IVF cycle
Outcomes	Hormonal and biochemical evaluation IVF cancellation rates Oocyte and embryo number Clinical pregnancy rates
Notes	Conducted in Italy, study dates not reported Funding source not reported
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Random‐number table
Allocation concealment (selection bias)	Low risk	Sequentially‐numbered sealed envelopes
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Unclear
Incomplete outcome data (attrition bias) All outcomes	Low risk	No dropouts
Selective reporting (reporting bias)	Low risk	Outcomes reported
Other bias	Low risk	No other bias found