| Methods | Double‐blind RCT | |
| Participants | Women undergoing ICSI (n not stated) | |
| Interventions | 1. Myo‐inostol 4 g and folic acid 400 μg: 1 tablet of each a day (n not stated) 2. Folic acid 400 μg: 1 tablet a day (n not stated) Taken for 3 months before ICSI and throughout pregnancy |
|
| Outcomes | Total rFSH units Number of stimulation days Fertilisation and cleavage rate Embryo quality Biochemical pregnancy rate Clinical pregnancy rate |
|
| Notes | Conducted in Italy, study dates not reported Conference abstract; percentages given but no total participant numbers available Funding by an institutional grant. An author was an employee of a pharmaceutical company Email sent to author 24th November 2015 Gianfranco.carlomagno@gmail.com; no reply. |
|
| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Random sequence generation (selection bias) | Unclear risk | "Patients were randomly assigned to two groups; MI treated or placebo" |
| Allocation concealment (selection bias) | Unclear risk | Not mentioned |
| Blinding (performance bias and detection bias) All outcomes | Low risk | "Double blind" |
| Incomplete outcome data (attrition bias) All outcomes | Unclear risk | Not mentioned |
| Selective reporting (reporting bias) | Unclear risk | Unknown |
| Other bias | Unclear risk | Unknown |
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