| Methods | Double‐blinded randomised control trial | |
| Participants | Women aged 18 ‐ 41 with PCOS which was clomiphene‐resistant who attended fertility clinic in Iran (n = 93) | |
| Interventions | 1. Oral NAC 1.2 g: 1 tablet a day (n = 53) 2. Vitamin C (?dose) (n = 40) |
|
| Outcomes | Oestradiol levels Number of follicles > 18 mm Endometrial thickness |
|
| Notes | Conducted in Iran, study began in 2010 (end unknown) Unknown trial duration Funding source not reported Tried to contact author regarding pregnancy data, uneven number in each group. No reply. |
|
| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Random sequence generation (selection bias) | Unclear risk | Not stated |
| Allocation concealment (selection bias) | Unclear risk | Not stated |
| Blinding (performance bias and detection bias) All outcomes | Unclear risk | Double‐blinded (another antioxidant, not placebo) |
| Incomplete outcome data (attrition bias) All outcomes | High risk | Uneven number in each group |
| Selective reporting (reporting bias) | Unclear risk | Unknown |
| Other bias | Low risk | No other bias found |
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