Methods | Randomised trial | |
Participants | Women undergoing IVF aged 22 ‐ 43 years. Mean age treatment group: 30.7 ± 4.5; placebo group: 28.8 ± 3.2) (n = 56) Inclusion criteria: non‐smokers, free from major illness including hypertension, all interested in becoming pregnant Exclusion criteria: myoma, adenomyosis, congenital abnormality, ovarian tumours, hormone or long‐term medication use |
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Interventions | 1. Multi‐vitamin/mineral (containing vitamins A, B, C, D, E and H, calcium, folic acid, nicotinic acid, iron, magnesium, phosphor copper, manganese and zinc): 1 tablet a day (n = 26) 2. Placebo (candy) (n = 30). for 45 days |
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Outcomes | Follicular fluid | |
Notes | Conducted in Turkey 3 groups were used in the study. The 1st group consisted of age‐matched controls, so we did not use these data in this review. The 2nd and 3rd groups were randomly assigned Author emailed on 1st August 2012 to ask for any data on pregnancy, live birth or adverse events. Author replied on 13th August 2012. No outcomes appropriate to this review. |
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Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Low risk | Randomised by a computer‐generated list |
Allocation concealment (selection bias) | Unclear risk | Not mentioned |
Blinding (performance bias and detection bias) All outcomes | High risk | Placebo used was candy |
Incomplete outcome data (attrition bias) All outcomes | Unclear risk | None mentioned |
Selective reporting (reporting bias) | Low risk | None known |
Other bias | Low risk | No other bias found |