Rizzo 2010

Methods	Prospective, randomised clinical trial
Participants	Women with low oocyte quality detected in previous IVF cycles (n = 65). Aged 35 ‐ 42 years. Mean age Treatment group 37.81 ± 2.61, Placebo 38.09 ± 1.97 IVF
Interventions	1. Myo‐inositol 2 g + folic acid 200 mg + melatonin 3 mg: each tablet twice a day (n = 32) 2. Myo‐inositol 2 g + folic acid 200 mg: each tablet twice a day (n = 33) Administered continuously from the day of GnRH administration
Outcomes	Embryo quality Pregnancy rate, biochemical and clinical Total number of oocytes retrieved (immature and mature oocytes) Fertilisation rate per number of retrieved oocytes and embryo cleavage rate Spontaneous abortion defined as a pregnancy loss from 5 ‐ 12 weeks pregnancy
Notes	Setting: Messina, Italy, study dates not reported All participants gave written informed consent for the procedure, and the study was approved by the local ethics committee. Source of funding unclear.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Randomised: "According to a randomisation table, patients were assigned to receive either 2 g..."
Allocation concealment (selection bias)	Unclear risk	Not stated
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Not stated
Incomplete outcome data (attrition bias) All outcomes	Low risk	No losses to follow‐up
Selective reporting (reporting bias)	Low risk	Data given for all outcomes reported in the text
Other bias	Low risk	No other bias found