Kvolik 2013.

Methods	Study design: prospective randomized study Sample size calculation: no information available
Participants	Number of randomized participants: 44 Inclusion criteria: adults, ASA I to III, undergoing thyroidectomy or breast cancer surgery Exclusion criteria: no information available
Interventions	Anaesthesia: induced with propofol 2 mg/kg and fentanyl 5 µg/kg; maintenance: no information available NMBA: single intubating dose: rocuronium 0.6 mg/kg Comparison: sugammadex 2 mg/kg (n = 20) vs neostigmine 50 µg/kg + atropine 25 µg/kg (n = 24) Administration time of sugammadex or neostigmine: reappearance of T2
Outcomes	Time to recovery of TOF 90% and mean increase in BIS indices per each minute after reversal
Notes	Publication type: meeting abstract Country: Croatia Conversions: none Authors’ conclusions: An increase in BIS index registered after reversal of rocuronium effects was faster during the recovery period among patients who were given sugammadex rather than neostigmine. Although a rapid increase in BIS indices was registered in the sugammadex group, more sensitive measurements are needed to confirm the clinical value of this observation Contact: first trial author Slavica Kvolik contacted by e‐mail: slavica.kvolik@os.t‐com.hr on 14.10.2015; no reply received
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Unable to assess owing to insufficient information
Allocation concealment (selection bias)	Unclear risk	Unable to assess owing to insufficient information
Blinding of participants (performance bias)	Unclear risk	Unable to assess owing to insufficient information
Blinding of personnel (performance bias)	Unclear risk	Unable to assess owing to insufficient information
Blinding of primary outcome assessment (detection bias)	Unclear risk	Unable to assess owing to insufficient information
Blinding of safety assessment (detection bias)	Unclear risk	Unable to assess owing to insufficient information
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Unable to assess owing to insufficient information
Selective reporting (reporting bias)	Unclear risk	Study protocol not available, but published meeting abstract clearly includes all expected outcomes
Funding bias	Unclear risk	Unable to assess owing to insufficient information
Other bias	Unclear risk	Unable to assess owing to insufficient information