NCT03116997.

Trial name or title	Study of recovery of strength after surgery comparing two different medications for reversal of muscle relaxant
Methods	Allocation: randomized Intervention model: parallel assignment Masking: participant, outcomes assessor Primary purpose: treatment
Participants	Estimated enrolment: 202 Inclusion criteria: ≥ 18 years of age and capable of giving consent Undergoing surgical procedures with expected length of 6 or fewer hours requiring NMB Exclusion criteria: Pregnancy History of documented anaphylaxis or contraindication to any of the study medications Surgical procedure for which both arms are required to be tucked at the patient's side Active coronary disease with a positive cardiac stress test History of severe chronic obstructive pulmonary disease (COPD) defined as FEV1 < 50% of predicted Serum creatinine ≥ 2.0 mg/dL Severe hepatic dysfunction accompanied by coagulopathy Chronic sustained release opioid use preop for longer than 2 weeks Use of toremifene Significant cognitive impairment or documented psychological impairment Myasthenia gravis or other neuromuscular disease Not eligible for standard anaesthetic induction (e.g. needing rapid sequence induction or awake fiberoptic bronchial intubation) ASA status > III
Interventions	Control group: At conclusion of surgery, neuromuscular blockade reversed with neostigmine/glycopyrrolate Intervention group: At conclusion of surgery, neuromuscular blockade reversed with sugammadex
Outcomes	Primary outcome measures: Measure participants' recovery time post surgery [Time Frame: 1 day] Determine whether sugammadex as compared with neostigmine decreases time for patients to be ready for discharge from the PACU post surgery
Starting date	7 April 2017
Contact information	United States, New Jersey Memoral Sloan Kettering Basking Ridge, Basking Ridge, New Jersey, United States United States, New York Memorial Sloan Kettering Cancer Center, Commack, New York, United StatesMemoral Sloan Kettering Westchester, Harrison, New York, United States Memorial Sloan Kettering Cancer Center, New York, New York, United States Contact: German Echeverry: echeverg@mskcc.org
Notes	Currently recruiting participants. Estimated Study Completion Date: April 2019