Table 6. Top 10 enriched pathways determined with DAVID from genes falling in across breed integrated Haplotype Score (iHS) selection signatures in four warmblood horse breeds.
| Term | %1 | p2 | Genes | FE3 | BH4 |
|---|---|---|---|---|---|
| nucleus (GO:0005634) | 23.08 | 9.37E-03 | HECW1, FAM96A, TRIP4, ONECUT1, IKZF1, CSNK1G1, USP3, FIGNL1, PGAM2, RPS27L, STK17A, PSMA2, GABPB1, MAPK6, PPIB, GCK, ZPBP, POLM, LEO1, GNB5, IGFBP3 | 1.77 | 0.65 |
| motor activity (GO:0003774) | 3.30 | 1.35E-02 | MYO5A, MYO1G, MYO5C | 16.67 | 0.74 |
| myosin complex (GO:0016459) | 3.30 | 1.39E-02 | MYO5A, MYO1G, MYO5C | 16.42 | 0.55 |
| ATP binding (GO:0005524) | 15.38 | 1.47E-02 | MYO5A, UBE2D4, DDX56, MAPK6, CSNK1G1, GCK, FIGNL1, MYO1G, CAMK2B, STK17A, DAPK2, ABCA13, ATP8B4, MYO5C | 2.05 | 0.52 |
| exocytosis (GO:0006887) | 3.30 | 1.95E-02 | MYO5A, MYO1G, YKT6 | 13.74 | 1.00 |
| ubiquitin-dependent protein catabolic process (GO:0006511) | 4.40 | 2.13E-02 | PSMA2, USP8, USP3, USP50 | 6.68 | 0.97 |
| IGF I binding (GO:0031994) | 2.20 | 3.02E-02 | IGFBP1, IGFBP3 | 64.45 | 0.64 |
| IGF II binding (GO:0031995) | 2.20 | 3.02E-02 | IGFBP1, IGFBP3 | 64.45 | 0.64 |
| ruffle (GO:0001726) | 3.30 | 3.39E-02 | MYO5A, DBNL, TLN2 | 10.22 | 0.73 |
| tropomyosin binding (GO:0005523) | 2.20 | 4.21E-02 | TMOD2, TMOD3 | 46.04 | 0.65 |
1% = percentage of genes involved in pathway relative to all genes used for analysis
2 p = p-value
3 FE = fold enrichment
4 BH = Benjamini-Hochberg test