Table 7. Top 10 enriched pathways determined with DAVID from genes falling in across breed Runs of Homozygosity (ROH) selection signatures in four warmblood horse breeds.
| Term | %1 | p2 | Genes | FE3 | BH4 |
|---|---|---|---|---|---|
| intermediate filament (GO:0005882) | 2.58 | 3.53E-07 | KRT26, KRT25, NES, KRT28, KRT27, KRT12, KRT20, IFFO1, KRT23, KRT24 | 10.32 | 3.69E-05 |
| embryonic skeletal system morphogenesis (GO:0048704) | 1.80 | 1.04E-04 | HOXB3, HOXB1, HOXB2, HOXB7, HOXB8, HOXB5, HOXB6 | 8.96 | 0.11 |
| structural molecule activity (GO:0005198) | 3.09 | 2.32E-04 | KRT26, KRT25, NES, KRT28, EPB41L1, KRT27, KRT12, LMNA, KRT20, IFFO1, KRT23, KRT24 | 3.93 | 0.06 |
| anterior/posterior pattern specification (GO:0009952) | 2.06 | 1.41E-03 | HOXB3, HOXB1, HOXB2, HOXB7, HOXB8, HOXB5, HOXB6, NEUROD1 | 4.74 | 0.53 |
| poly(A) RNA binding (GO:0044822) | 8.76 | 1.48E-03 | FASTKD1, MTDH, PNPT1, HDGF, TRMT10A, WBP11, CCT3, MTIF2, POLR2B, MOV10, ARL6IP4, NQO1, FNDC3A, TOP2A, RBM12, RPS27A, ZCCHC8, NIP7, MEX3A, TBRG4, SSB, NOA1, ISG20L2, CASC3, DDX56, DDX55, PPIG, NOP2, EIF4E, HOXB6, POP1, SRP72, RBM39, WDR43 | 1.77 | 0.19 |
| IGF I binding (GO:0031994) | 0.77 | 5.29E-03 | IGFBP1, IGFBP3, IGFBP4 | 25.35 | 0.40 |
| IGF II binding (GO:0031995) | 0.77 | 5.29E-03 | IGFBP1, IGFBP3, IGFBP4 | 25.35 | 0.40 |
| chondrocyte differentiation (GO:0002062) | 1.29 | 6.39E-03 | MEF2D, BMP2, WNT5B, GDF5, WNT2B | 6.61 | 0.90 |
| hematopoietic progenitor cell differentiation (GO:0002244) | 1.55 | 1.12E-02 | HOXB3, PTPN6, ARL11, GPATCH4, REST, TOP2A | 4.41 | 0.95 |
| regulation of IGF receptor signaling pathway (GO:0043567) | 0.77 | 1.21E-02 | IGFBP1, IGFBP3, IGFBP4 | 17.01 | 0.93 |
1% = percentage of genes involved in pathway relative to all genes used for analysis
2 p = p-value
3 FE = fold enrichment
4 BH = Benjamini-Hochberg test