| Outcome |
Scale |
Studies |
Pooled summary stats |
Heterogeneity |
Single study results |
Stat sig? |
% change on placebo |
Comments |
| Symptom score ‐ dyspnoea daytime |
|
Ahonen 1978 Salorinne 1988 Wheeler 1987 |
Paired mean difference
‐0.09 (95%CI ‐0.14, ‐0.04) |
p = 0.45,
I‐squared = 0% |
|
Y |
15% decrease
(i.e., favours anticholinergic) |
Wheeler:
rho = 0.817 |
| Symptom score ‐ dyspnoea daytime (no Salorinne) |
1‐4
0‐3 |
Ahonen 1978
Wheeler 1987 |
Paired mean difference
‐0.07 (95%CI ‐0.13, ‐0.02) |
p = 0.97,
I‐squared = 0% |
|
Y |
12% decrease |
Wheeler:
rho = 0.817 |
| Symptom score ‐ cough daytime |
1‐4
0‐3 |
Ahonen 1978
Salorinne 1988 |
|
|
Mean difference
Aho ‐0.05 (95%CI ‐0.16, 0.06)
Sal ‐0.05 (no SDs) |
N |
10% decrease
11% decrease |
|
| Symptom score ‐ dyspnoea night‐time |
1‐4
0‐3 |
Ahonen 1978
Salorinne 1988 |
|
|
Mean difference
Aho ‐0.13 (95%CI ‐0.27, 0.01)
Sal ‐0.09 (no SDs) |
N |
24% decrease
26% decrease |
|
| Symptom score ‐ cough night‐time |
0‐3 |
Salorinne 1988 |
|
|
Mean difference
+0.04 (no SDs) |
N |
14% Increase
(i.e. anticholinergic worse than placebo) |
|
| Symptom score ‐ night‐time overall score |
0‐3 |
Wheeler 1987 |
|
|
Paired mean difference
+0.09 (95%CI ‐0.09, 0.26) |
N |
28% Increase |
Wheeler:
rho = 0.611 |
| Clinical score ‐ day and night (change score) |
0‐13 |
Taytard 1984 |
|
|
Mean difference (parallel trial)
‐0.72 (95%CI ‐1.37, ‐0.07) |
Y |
71% decrease |
|
