| Outcome |
Time (post dose) |
Studies |
Pooled summary stats |
Heterogeneity |
Single study results |
Stat sig? |
% on placebo mean |
Comments |
| Daily PEFR am pre‐bronchodilator |
07.00 (6h)
08.00 (10h)
"on rising"
(12h) |
Ahonen 1978
Salorinne 1988
Wheeler 1987 |
Paired mean difference
14.38 L/min
(95%CI 7.69, 21.08) |
p = 0.22
I‐squared = 34% |
|
Y |
7% increase
(i.e. favours Antichol) |
Wheeler:
rho = 0.919 |
| Daily PEFR am pre‐bronchodilator (no Salorinne) |
07.00 (6h) "on rising" (12h) |
Ahonen 1978 Wheeler 1987 |
Paired mean difference
16.26 l/min
(95%CI 9.21, 23.31) |
p = 0.65
I‐squared = 0% |
|
Y |
5% increase |
|
| Daily PEFR pm
pre‐bronchodilator |
22.00 (3h)
22.00 (4h)
"on retiring" (12h) |
Ahonen 1978
Salorinne 1988
Wheeler 1987 |
Paired mean difference
23.48 l/min
(95%CI 12.32, 34.65) |
p = 0.01
I‐squared = 78% |
|
Y |
7% increase |
Wheeler:
rho = 0.911 |
| Daily PEFR am
post‐bronchodilator |
10.00 (3h)
10.00 (2h) |
Ahonen 1978
Salorinne 1988 |
Paired mean difference
34.91 l/min
(95%CI 20.13, 49.70) |
p = 0.06
I‐squared = 71% |
|
Y |
9% increase |
|
| Daily PEFR pm
post‐bronchodilator |
00.00 (2h) |
Salorinne 1988 |
|
|
Paired mean diff.
23.94 L/min
(95%CI 5.20, 42.68) |
Y |
7% increase |
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