| Studies |
Design&Duration |
Ratio BA |
Outcome |
Time (post dose) |
Single study results |
Stat sig? |
%change on BA |
| Philip‐Joet 1990 |
Parallel design
1 week measurements only used (see text) |
1:2
Comb : single |
PEFR am
PEFR pm
PEFR am post dose
PEFR pm
post dose |
NS (NS but qid, so guess 6h)
Not Stated (NS)
NS (20 mins)
NS (20 mins) |
Mean difference
4.65 l/m (95%CI ‐26.24, 35.54)
MD 8.17 l/m (95%CI ‐24.08, 40.42)
MD 3.31 l/m (95%CI ‐29.78, 36.40)
MD ‐4.61 l/m (95%CI ‐37.93, 28.71) |
N
N
N
N |
2% increase (i.e. in favour of combination)
3% increase
1% increase
1% decrease |
| Haahtela 1991 |
Parallel design
12 weeks |
1:2
Comb :
Single |
PEFR am
PEFR pm
PEFR am
post dose
PEFR pm
post dose |
07.00h (NS but qid so guess 6h)
19.00h (NS)
07.00h (1h post dose)
19.00h (1h post dose) |
Mean difference +2 (Duovent/Sal)
Mean difference ‐4 l/m (Berodual/Sal)
Mean difference 6 l/m (Duovent/Sal)
Mean difference 2 l/m (Berodual/Sal)
Mean difference 10.5 l/m (Duo/Sal)
Mean difference ‐2 l/m (Bero/Sal)
Mean difference 10 l/m (Duo/Sal)
Mean difference ‐2.5 l/m (Bero/Sal) |
"N" authors
"N" authors
"N" authors
"N" authors |
1% increase
1% decrease
1% increase
1% increase
2% increase
0.5% decrease
2% increase
1% decrease |
| Haahtela 1991 |
Parallel design
12 weeks |
1:1
Comb : single |
PEFR am
PEFR pm
PEFR am
post dose
PEFR pm
post dose |
07.00h (NS but qid so guess 6h)
19.00h (NS)
07.00h (1h post dose)
19.00h (1h post dose) |
Mean difference +1.5 litres/min
Mean difference 9.5 l/m
Mean difference 15 l/m
Mean difference 14 l/m |
"N" authors
"N" authors
"N" authors
"N" authors |
0.5% increase
2% increase
3% increase
3% increase |
| Wolstenholme 1989 |
Crossover design
4 weeks |
1:1
Comb : single |
PEFR am
PEFR pm
PEFR am
post dose
PEFR pm
post dose |
NS (NS but qid so guess 6h)
NS (NS)
NS (30mins)
NS (30 mins) |
Mean difference
‐8.70 l/m (95%CI ‐83.66, 66.26)
Mean difference
‐1.70 l/m (95%CI ‐89.35, 85.95)
Mean difference
‐3.00 l/m (95%CI ‐78.77, 72.77 )
Mean difference
‐4.20 l/m (95%CI ‐76.47, 68.07 ) |
N
N
N
N |
3% decrease
0.5% decrease
1% decrease
1% decrease |
| Tammivaara 1993 |
Crossover design 3 weeks beta‐agonist was oral CR terbutaline |
1:1 Comb : single |
PEFR am PEFR pm |
08.00h (12h post dose) 20.00h (4h post ipratropium, 12h after oral terbutaline) |
Mean difference ‐5.00 l/m (95%CI ‐50.72, 40.72 ) Mean difference 0.00 l/m (95%CI ‐47.48, 47.48 ) |
N N |
1% decrease no difference |
| Pierce 1982
FLOW not peak flow |
Crossover design
4 weeks |
1:1
Comb : single |
Flow am
Flow pm
Flow pm
post dose |
08.00h (6h post dose)
19.00h (NS; probably 5‐6h post dose)
20.00h (1h post dose) |
Mean difference
3.40 litres (95%CI ‐4.18, 10.98 )
Mean difference
6.86 litres (95%CI ‐5.03, 18.75 )
Mean difference
11.59 litres (95%CI ‐4.61, 27.79 ) |
N
N
N |
48% increase
48% increase
57% increase |
