| Methods |
Crossover design; each phase 14 days. All patients completed the study correctly. Said to be double blind (vs placebo), but no details. Concurrent asthma medication unclear, but none had oral steroids or anticholinergics; 200µg salbutamol given each morning and evening as part of test procedure. |
| Participants |
Inclusion criteria: patients had documented nocturnal asthma ‐ difference of >20% in PEFR between evening and morning readings; nocturnal asthma. Patient details: 18 participants (M/F 7/11); age 18‐76; mild‐severe asthma (heterogeneous severity); 10:8 atopy; no information on concurrent COPD. |
| Interventions |
3 interventions: oxitropium bromide 200 and 400µg, placebo ; all interventions taken once at night. |
| Outcomes |
Daily PEF, morning and evening (no results or SDs); difference in PEFR (evening‐morning) ‐ not analysed; rescue medication ‐ no results; daily symptom scores ‐ no data. |
| Notes |
200µg salbutamol given each morning and evening as part of test procedure. |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment (selection bias) |
Unclear risk |
Information not available (Cochrane Grade B) |
