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. 2004 Jul 19;2004(3):CD003269. doi: 10.1002/14651858.CD003269.pub2

Ruffin 1990.

Methods Crossover design; phase length unclear ‐ could be 8 weeks. 5/21 patients withdrew from study. Said to be double blind (vs placebo), but no other details. Concurrent medication: not stated.
Participants Inclusion criteria: patients had asthma ‐ diagnosis reasons not stated. Patient details: 16 remaining participants (M/F 9/7); mean age 56; mild asthma; no information about atopy or concurrent COPD.
Interventions 2 interventions: oxitropium bromide 200µg and placebo; both interventions t.i.d. (not stated when).
Outcomes PEF (am and pm, probably at end of period); FEV1 at end of period.
Notes Abstract; funded by Boehringer Ingelheim.
Risk of bias
Bias Authors' judgement Support for judgement
Allocation concealment (selection bias) Unclear risk Information not available (Cochrane Grade B)