| Methods |
Crossover design, but analysed as 1st period only; each phase 21 days. All patients completed the study (although there is no patient number 2). Said to be double blind (with identical treatments), but no details about the assessor. Concurrent asthma medication: no oral or inhaled steroids, no regular treatment but 8 had theophylline for relief. |
| Participants |
Inclusion criteria: patients had asthma ‐ diagnosis according to ATS criteria; presenting an allergic diathesis and consulting an allergology unit; perennial asthma. Patient details: 16 participants (M/F 9/7); age 14‐48 (mean 31); mild asthma; all atopic, no information on concurrent COPD. |
| Interventions |
2 interventions: oxitropium bromide 200µg and placebo; all interventions t.i.d. (08.00, 14.00, 20.00h). |
| Outcomes |
Clinical scores (IPD); rescue medication; patient rating. |
| Notes |
Significant order effect, so used 1st period data only from IPD. |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment (selection bias) |
Unclear risk |
Information not available (Cochrane Grade B) |
