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. Author manuscript; available in PMC: 2019 Apr 25.
Published in final edited form as: Cell Rep. 2018 Apr 3;23(1):11–22. doi: 10.1016/j.celrep.2018.03.040

Figure 2. Refinement of Preganglionic Axons Requires Postsynaptic Activity.

Figure 2.

(A–C) Left: representative compound EPSPs evoked in an SCG neuron from (A) α3-KO mice 1 month after rescue (see inset), (B) P60 α3-KO mice, and (C) P60 WT mice. Middle: the EPSPs evoked by individual preganglionic axons are shown. DI, disparity index. Right: distribution of the SCG neurons innervated by the number of inputs; each distribution is fit with a Gaussian function. The distribution for α3-KO rescue neurons is not significantly different from P60 WT (p > 0.2), but it is significantly different from P60 α3 KO (p < 0.001). Each distribution in (A)–(C) contains data from at least 4 mice. n, number of neurons.

(D) The average difference in strength between the strongest and second strongest inputs, expressed as a percentage of the maximum compound EPSP. Error bars represent ± SEM. ***p < 0.001.