Fig. 4.

Temporal (IT) and frontal (MF) immnudensities of the major complexes quantified in the study in brains of MAP participants stratified by (a) CERAD scale, (b) Braak stage, or (c) clinical diagnosis. Bars are mean ± standard error. Datasets were analyzed by ANCOVA, using each protein complex measure as the dependent variable in separate models, CERAD/Braak/clinical diagnoses as the dependent variables, and sex, age, and PMI as covariates. *P < 0.05, **P < 0.01, and ***P < 0.001, FDR-corrected P-values in ANCOVA followed by Dunnet’s post hoc test.