Table 2.

Linear regression models^a showing the associations between most relevant presynaptic complexes identified in the IT and MF of MAP participants (n = 140), as predictors, and global cognitive function as the outcome

Model terms	Reference Model		Model 1		Model 2		Model 3
	Adj. R2 or β	FDR P-value	Adj. R2 or β	FDR P-value	Adj. R2 or β	FDR P-value	Adj. R2 or β	FDR P-value
Model adj. R2	0.3099		0.3991		0.3963		0.4398
Age at death	−0.1681	0.0605	−0.1459	0.0797	−0.1882	0.02 02*	−0.1663	0.03 40*
Sex	0.0568	0.5450	0.0197	0.7854	0.0282	0.6972	0.0075	0.9144
Education	−0.1058	0.3606	−0.1084	0.2598	−0.1060	0.2775	−0.1079	0.2225
PMI	−0.0698	0.5450	−0.0555	0.7175	−0.0798	0.4498	−0.0665	0.5352
Macroinfarcts	−0.0513	0.5450	−0.0299	0.7854	−0.0459	0.6972	−0.0312	0.7007
Lewy bodies	−0.2647	0.0075*	−0.2560	0.0027*	−0.2353	0.0077*	−0.2363	0.0068*
Hippocampal sclerosis	−0.0190	0.8153	−0.0242	0.7854	−0.0361	0.6972	−0.0356	0.7007
p-amyloidb	−0.2475	0.0161*	−0.2277	0.0136*	−0.2336	0.0109*	−0.2222	0.0102*
Phosphotaub	−0.2276	0.0241*	−0.1678	0.0797	−0.1925	0.0340*	−0.1563	0.0852
Synapse densityc	0.0710	0.5450	−0.0444	0.7414	0.0286	0.6972	−0.0476	0.6604
IT 150k STX1	–	–	0.3311	0.0002*	–	–	0.2499	0.0068*
MF 500k CPLX1/2 ratiod	–	–	–	–	0.3009	0.0002*	0.2236	0.0068*

Abbreviations: CPLX, complexin; FDR, false discovery rate; IT, inferior temporal gyrus; MF, middle-frontal gyrus; PMI, postmortem interval; S.E., standard error; STX1, syntaxin-1.

^aModels 1–3 were constructed sequentially by adding the indicated terms to the reference model. Whole model adjusted R², individual standardized coefficients (β) and FDR-adjusted p-values are reported.

^bOverall brain load.

^cSynapse density was estimated as the overall brain levels of the three SNARE proteins (syntaxin-1, SNAP-25 and VAMP) averaged.

^dRatio between complexin-I (GABAergic) to complexin-II (glutamatergic) 500-kDa complexes.

^*Statistically significant.