| 1 Tranquillisation or asleep ‐ not asleep |
2 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
| 1.1 at 1 hour |
1 |
60 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.05 [0.76, 1.44] |
| 1.2 by 3 hours |
1 |
66 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.93 [1.14, 3.27] |
| 2 Repeated need for rapid tranquillisation |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
| 2.1 more than 1 injection |
1 |
66 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.14 [0.91, 1.43] |
| 2.2 more than 3 injections |
1 |
66 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.11 [0.50, 2.45] |
| 3 Global outcome: 1. No overall improvement |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
| 3.1 by 30 minutes |
1 |
44 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.10 [0.70, 1.71] |
| 3.2 at 1 hour |
1 |
44 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.64 [0.54, 5.03] |
| 3.3 at > 1 hour |
1 |
44 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
| 4 Mental state: 1a. Average scores ‐ i. up to 2 hours |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 4.1 endpoint score at 1 hour (BPRS, high=worse) |
1 |
37 |
Mean Difference (IV, Fixed, 95% CI) |
3.26 [‐4.13, 10.65] |
| 4.2 endpoint score at 2 hours (BPRS, high=worse) |
1 |
37 |
Mean Difference (IV, Fixed, 95% CI) |
4.07 [‐2.62, 10.76] |
| 5 Mental state: 1b. Average scores ‐ ii. up to 4 hours |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 5.1 endpoint score at 3 hours (BPRS, high=worse) |
1 |
37 |
Mean Difference (IV, Fixed, 95% CI) |
5.03 [‐2.98, 13.04] |
| 5.2 endpoint score at 4 hours (BPRS, high=worse) |
1 |
37 |
Mean Difference (IV, Fixed, 95% CI) |
1.73 [‐6.14, 9.60] |
| 6 Adverse effects: 1a. General |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
| 6.1 one or more drug‐related adverse effect up to 24 hours |
1 |
66 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.13 [0.60, 2.10] |
| 7 Adverse effects: 1b. General ‐ serious |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
| 8 Adverse effects: 2a. Specific ‐ anticholinergic |
1 |
66 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.53 [0.14, 2.04] |
| 8.1 dry mouth up to 24 hours (only reported if occurred ≥9%) |
1 |
66 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.53 [0.14, 2.04] |
| 9 Adverse effects: 2b. Specific ‐ arousal |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
| 9.1 asleep ‐ at 1 hour |
1 |
60 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.89 [0.40, 1.99] |
| 10 Adverse effects: 2c. Specific ‐ cardiovascular |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
| 10.1 dizziness (only reported if occurred in ≧9%) ‐ during 24 hours |
1 |
66 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.89 [0.19, 4.07] |
| 10.2 hypertension ‐ use of additional clonidine ‐ during 24 hours |
1 |
66 |
Risk Ratio (M‐H, Fixed, 95% CI) |
2.67 [0.11, 63.17] |
| 11 Adverse effects: 2d. Specific ‐ movement disorder |
2 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
| 11.1 ataxia (only reported if occurred in ≧9%) ‐ during 24 hours |
1 |
66 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.44 [0.04, 4.65] |
| 11.2 dystonia (only reported if occurred in ≧9%) ‐ during 24 hours |
1 |
66 |
Risk Ratio (M‐H, Fixed, 95% CI) |
3.54 [0.42, 30.03] |
| 11.3 EPS |
1 |
60 |
Risk Ratio (M‐H, Fixed, 95% CI) |
15.0 [2.11, 106.49] |
| 11.4 hypertonia/rigidity (only reported if occurred in ≧9%) ‐ during 24 hours |
1 |
66 |
Risk Ratio (M‐H, Fixed, 95% CI) |
6.22 [0.33, 115.91] |
| 11.5 speech disorder (only reported if occurred in ≧9%) ‐ during 24 hours |
1 |
66 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.77 [0.35, 9.01] |
| 11.6 tremor (only reported if occurred in ≧9%) ‐ during 24 hours |
1 |
66 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.77 [0.17, 18.60] |
| 11.7 use of additional benztropine ‐ during 24 hours |
1 |
66 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.99 [0.68, 5.83] |
