Bailine 1987.

Methods	Allocation: randomised. Blindness: blind for some outcomes. Duration: 72 hours.
Participants	Diagnosis: Research Diagnostic Criteria (11) diagnosis of schizophrenia, any type, or manic depressive illness, manic type and grossly abnormal behavior. N = 34. Age: mean 25.2 years. Sex: 26 males, 8 females. History: "violent or assaultive or too psychologically disorganized to be maintained on a unit without significant extra supervision." (p.128). Excluded: not reported. Setting: inpatient, USA.
Interventions	1. Haloperidol IM: dose 5 mg or 10 mg/IM, maximum cumulative dose of 100 mg during 24 hours (mean number of IMs not reported). N = 20. 2. Chlorpromazine IM: dose 50 mg or 100 mg/IM, maximum cumulative dose of 500 mg during 24 hours (mean number of IMs not reported). N = 14.
Outcomes	Adverse events: leaving the study early. Unable to use: Mental state: BPRS (mean and overall P value only for significant findings reported, SD/SE/CI not reported). Global state: GAS (not published, mean and overall P value only for significant findings reported, SD/SE/CI not reported). Global state: NOSIE (overall P value only for significantly findings reported, mean/SD/SE/CI not reported). Adverse events: SAS (overall P value only for significantly findings reported, mean/SD/SE/CI not reported).
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	"random number sequence".
Allocation concealment (selection bias)	Unclear risk	Not stated.
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Not stated.
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	BPRS was rater‐blinded. However, it is not clear whether other outcomes were blinded.
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	It is reported that no one discontinued due to adverse effects, however it does not state if there were discontinuations due to any other reason.
Selective reporting (reporting bias)	High risk	Only the significant findings/factors are reported for a number of outcomes.
Other bias	High risk	Small short study.