Resnick 1984.
Methods | Allocation: randomised. Blindness: double. Duration: 24 hours. |
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Participants | Diagnosis: acute agitation. N = 27. Age: range 18‐65 years. Sex: not reported. History: involuntary hospitalised. Excluded: intoxicated, known sensitivity to droperidol or haloperidol, evidence of active renal, hepatic, or cardiac disease. Setting: emergency and psychiatric crisis unit, USA. |
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Interventions | 1. Haloperidol: dose up to 4 injections of 5 mg (mean number of IMs not reported). N = 16. 2. Droperidol: dose up to 4 injections of 5 mg (mean number of IMs 1.36). N = 11. |
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Outcomes | Global state: need for additional injection. Adverse effects: reporting of EPS. Unable to use: Mental state: BPRS (mean/SD/SE/CI not reported). Adverse effects: it is reported that there were no significant changes in blood pressure, pulse rate and respirations, however no data given. |
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Notes | ||
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Described as randomised ‐ method of randomisation is not reported. |
Allocation concealment (selection bias) | Low risk | "packages of medication were identified only by a code which was kept in the pharmacy until the conclusion of the study" (p.298). |
Blinding of participants and personnel (performance bias) All outcomes | Low risk | "packages of medication were identified only by a code which was kept in the pharmacy until the conclusion of the study" (p.298). |
Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | Described as double‐blind, however no further details reported regarding rater blinding. |
Incomplete outcome data (attrition bias) All outcomes | Low risk | No evidence of incomplete data. |
Selective reporting (reporting bias) | Low risk | No evidence of selective reporting. |
Other bias | High risk | Small short study. |