Yin 2012.
Methods | Allocation: randomised. Blinding: researcher‐blinded. Duration: 72 hours. |
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Participants | Diagnosis: ICD‐10 diagnosis of schizophrenia. N = 60 Age: range 20‐54 years. Sex: 33 males, 27 females. History: acute agitation; length of Illness: 1‐ 23 years. Excluded: "taking ziprasidone 3 months before recruitment; taking other schizophrenia medications 12 hours before recruitment; taking long‐term schizophrenia medication 2 weeks before recruitment; additive to drugs 3 months before recruitment; ECG irregular (QTc > 500msec)". Setting: inpatients, China. |
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Interventions | 1. Haloperidol: starting dose 5 mg/IM/day; maximum dose 20 mg. N = 30. 2. Ziprasidone: starting dose 10 mg/IM/day; maximum dose 40 mg. N = 30. |
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Outcomes | Mental state: BPRS total. Adverse effects. Adverse effects: movement ‐ SAS. |
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Notes | *It is not clear if this paper presents the results from one centre of the Fang 2012 multi‐centre trial. Attempted to contact author to clarify. | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Described as randomised ‐ method of randomisation is not reported. |
Allocation concealment (selection bias) | Unclear risk | Not stated. |
Blinding of participants and personnel (performance bias) All outcomes | Unclear risk | Researcher blinded to assignment. |
Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | Not stated. |
Incomplete outcome data (attrition bias) All outcomes | Low risk | No evidence of incomplete outcome data. |
Selective reporting (reporting bias) | Low risk | No evidence of selective reporting. |
Other bias | Low risk | None obvious. |