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. 2017 Jul 31;2017(7):CD009377. doi: 10.1002/14651858.CD009377.pub3

Esmailian 2015.

Methods Allocation: randomised.
Blindness: double.
Duration: not stated.
Participants Diagnosis: patients who referred to the emergency department because of medical diseases, drug poisoning, or trauma, and need the sedative agent to sedation.
N = 48.
Age: 18‐65 years.
Sex: 36 males and 12 females.
History: internal (N = 36)*, drug poisoning (N = 2), trauma (N = 10).
Exclusion: sensitivity to haloperidol or midazolam, contraindications to these drugs, sympathomimetic agents, agitation because of reversible factors (such as hypotension, hypoxia, and hypoglycaemia), tachycardia or bradycardia, respiratory distress, pregnancy, symptoms of withdrawal syndrome, and receiving sedative agents within the past 12 hours.
Setting: emergency department, Iran.
Interventions 1. Haloperidol: fixed dose 5 mg/IM.
2. Midazolam: flexible doses 2.5 mg/IM to 5 mg/IM according to weight.
Outcomes General: time to sedation, time to full consciousness, need for additional doses, need for re‐sedation within 60 minutes.
Adverse effects.
Notes *not clear which diagnosis includes; an attempt to contact the authors was made (3rd July 2016).