周德祥, 2012.
Methods | Allocation: randomised. Blindness: not stated. Duration: 7 days. |
Participants | Diagnosis: CCMD‐3 diagnosis of schizophrenia. N = 65. Age: range 18‐60 years. Sex: 36 males, 29 females. History: acute psychotic agitation; length of Illness of 1.1 to 22.3 months. Excluded: pregnancy, serious physical illness, addiction to alcohol or drugs. Setting: inpatients, China*. |
Interventions | 1. Haloperidol: dose 10 mg/IM/day to 20 mg/IM/day. N = 32. 2. Risperidone: dose 4 mg/oral/day to 6 mg/oral/day + clonazepam dose 2 mg/oral/day to 4 mg/oral/day. N = 33. |
Outcomes | Unable to use: Mental state: PANSS total (data not reported). Agitation: PANSS‐EC (data not reported). Adverse events (data not reported). |
Notes | *It is not clear if this paper presents the results from one centre of the Fang 2012 multi‐centre trial. Authors contact unavailable. |
ACES: Agitation‐Calmness Evaluation Scale AIMS: Abnormal Involuntary Movement Scale BARS: Behavioural Activity Rating ScaleBAS: Barnes Akathisia Scale BPRS: Brief Psychiatric Rating Scale CABS: Corrigan Agitated Behavior Scale CCMD: Chinese Classification of Mental Disorders CGI: Clinical Global Impression CGI‐I: Clinical Global Impression – Improvement CGI‐S: Clinical Global Impression – Severity CI: confidence interval DSM: Diagnostic and Statistical Manual ECG: electrocardiogram ECT: electroconvulsive therapy EPS: Extrapyramidal Side Effects ICD: International Classification of Diseases IM: intramuscular OAS: Overt Aggression Scale PANSS: Positive and Negative Syndrome Scale PANSS‐EC: Positive and Negative Syndrome Scale Excited Component p.o.: by mouth RSESE: Rating Scale for Extrapyramidal Side Effects. SAS: Simpson‐Angus Scale SD: standard deviation SE: standard error TESS: Treatment Emergent Symptom Scale TSRS: TSRS ‐ Target Rating Symptom Scale YMRS ‐ Young Mania Rating Scale