Study	Reason for exclusion
Athyros 2002	Publication type letter, no control group, not enough information reported.
Braaskamp 2015b	Cohort study.
Braaskamp 2015c	Clinical trial without randomization.
Carreau 2011	Cohort study.
Chan 2016	No control group without medication.
Dirisamer 2003	Clinical trial, no control group.
Gandelman 2011	Clinical trial, no control group, open‐label.
Hedman 2003	Clinical trial, no control group.
Hedman 2005	Clinical trial, no control group.
Lambert 1996	Clinical trial, no control group.
Langslet 2016	Clinical trial, no placebo control group
McCrindle 2002	Randomised cross‐over trial, comparison unacceptable (i.e. combination of 2 active drugs): one intervention was 10 mg pravastatin plus 5 g colestipol and the other 10 g colestipol.
Raal 1997	Clinical trial, no control group.
Sinzinger 2004	Cohort study.
Stefanutti 1999	Clinical trial, control diet alone, controls were not clearly defined, e.g. the diagnostic criteria for heterozygous FH not reported, only age of the participants given.
Stein 1989	Cohort study.
Stein 2016	Participants had homozygous FH.
Tada 2016	No control group without medication.
Teramoto 2016	PCSK 9 inhibitor used as add‐on therapy and also not only people with FH included.
van der Graaf 2006	Clinical trial, no control group.

FH: familial hypercholesterolemia