Summary of findings for the main comparison. Natural cycle FET versus HT FET.
| Natural cycle FET versus HT FET | ||||||
| Population: subfertile women Settings: assisted reproductive technology clinics Intervention: natural cycle FET Comparison: HT FET | ||||||
| Outcomes | Illustrative comparative risks* (95% CI) | Relative effect (95% CI) | No of participants (studies) | Quality of the evidence (GRADE) | Comments | |
| Assumed risk | Corresponding risk | |||||
| HT FET | Natural cycle FET | |||||
| Live birth rate per woman | No data available | Not estimable | ‐ | |||
| Miscarriage rate per woman | No data available | Not estimable | ‐ | |||
| Ongoing pregnancy rate per woman | No data available | Not estimable | ‐ | |||
| Multiple pregnancy rate per woman | See comment | OR 2.48 (0.09 to 68.14) | 21 (1 study) | ⊕⊝⊝⊝ very low1,2 | No events in the control group | |
| *The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: confidence interval; FET: frozen‐thawed embryo transfer; HT: hormone therapy; OR: odds ratio | ||||||
| GRADE Working Group grades of evidence High quality: We are very confident that the true effect lies close to that of the estimate of the effect Moderate quality: We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different Low quality: Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect Very low quality: We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect | ||||||
1Downgraded one level for serious risk of bias: study at unclear risk of bias in all domains. 2Downgraded two levels due to very serious imprecision: single study, very few events. Confidence intervals compatible with benefit in either group or with no effect.