Summary of findings 2. Natural cycle FET versus HT plus GnRHa suppression FET.
| Natural cycle FET versus HT + GnRHa suppression FET | ||||||
| Population: subfertile women Settings: assisted reproductive technology clinics Comparison: HT + GnRHa FET | ||||||
| Outcomes | Illustrative comparative risks* (95% CI) | Relative effect (95% CI) | No of participants (studies) | Quality of the evidence (GRADE) | Comments | |
| Assumed risk | Corresponding risk | |||||
| HT + GnRHa FET | Natural cycle FET | |||||
| Live birth rate per woman | 316 per 1000 | 262 per 1000 (153 to 414) | OR 0.77 (0.39 to 1.53) | 159 (1 study) | ⊕⊕⊝⊝ low1 | Only 46 events |
| Miscarriage rate per woman | No data available | Not estimable | ‐ | |||
| Ongoing pregnancy rate per woman | No data available | Not estimable | ‐ | |||
| Multiple pregnancy rate per woman | 63 per 1000 | 38 per 1000 (9 to 144) | OR 0.58 (0.13 to 2.50) | 159 (1 study) | ⊕⊕⊝⊝ low1 | Only 8 events |
| *The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: confidence interval; FET: frozen‐thawed embryo transfer; GnRHA: gonadotrophin‐releasing hormone agonist; HT: hormone therapy; OR: odds ratio | ||||||
| GRADE Working Group grades of evidence High quality: We are very confident that the true effect lies close to that of the estimate of the effect Moderate quality: We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different Low quality: Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect Very low quality: We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect | ||||||
1Downgraded two levels due to very serious imprecision: single study, few events, confidence interval compatible with benefit in either group or with no effect.