Summary of findings 4. Modified natural cycle FET (HCG trigger) versus HT FET.
| Modified natural cycle FET (HCG trigger) versus HT FET | ||||||
| Population: subfertile women Settings: assisted reproductive technology clinics Intervention: modified natural cycle FET (HCG trigger) Comparison: HT FET | ||||||
| Outcomes | Illustrative comparative risks* (95% CI) | Relative effect (95% CI) | No of participants (studies) | Quality of the evidence (GRADE) | Comments | |
| Assumed risk | Corresponding risk | |||||
| HT FET | Modified natural cycle FET (HCG trigger) | |||||
| Live birth rate per woman | 88 per 1000 | 114 per 1000 (78 to 165) | OR 1.34 (0.88 to 2.05) | 959 (1 study) | ⊕⊕⊝⊝ low1,2 | |
| Miscarriage rate per woman | No data available | Not estimable | ‐ | |||
| Ongoing pregnancy rate per woman | 97 per 1000 | 115 per 1000 (79 to 164) | OR 1.21 (0.80 to 1.83) | 959 (1 study) | ⊕⊕⊝⊝ low1,2 | |
| Multiple pregnancy rate per woman | No data available | Not estimable | ‐ | |||
| *The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: confidence interval; FET: frozen‐thawed embryo transfer;HCG: human chorionic gonadotrophin; HT: hormone therapy; OR: odds ratio. | ||||||
| GRADE Working Group grades of evidence High quality: We are very confident that the true effect lies close to that of the estimate of the effect Moderate quality: We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different Low quality: Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect Very low quality: We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect | ||||||
1Downgraded one level due to serious risk of bias: high attrition rate, unclear risk of allocation concealment 2Downgraded one level due to serious imprecision: confidence intervals compatible with benefit in either group or with no effect