Summary of findings 5. Modified natural cycle FET (HCG trigger) versus HT + GnRHa suppression FET.
| Modified natural cycle FET (HCG trigger) versus HT + GnRHa FET | ||||||
| Population: subfertile women Settings: assisted reproductive technology clinics Intervention: modified natural cycle FET (HCG trigger) Comparison: HT + GnRHa FET | ||||||
| Outcomes | Illustrative comparative risks* (95% CI) | Relative effect (95% CI) | No of participants (studies) | Quality of the evidence (GRADE) | Comments | |
| Assumed risk | Corresponding risk | |||||
| HT + GnRHa FET | Modified natural cycle FET (HCG trigger) | |||||
| Live birth rate per woman | 398 per 1000 | 423 per 1000 (304 to 553) | OR 1.11 (0.66 to 1.87) | 236 (1 study) | ⊕⊕⊝⊝ low1,2 | |
| Miscarriage rate per woman | 68 per 1000 | 51 per 1000 (18 to 138) | OR 0.74 (0.25 to 2.19) | 236 (1 study) | ⊕⊕⊝⊝ low1,2 | |
| Ongoing pregnancy rate | No data available | Not estimable | ‐ | |||
| Multiple pregnancy rate per woman | No data available | Not estimable | ‐ | |||
| *The basis for the assumed risk is the mean control group risk across studies. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: confidence interval; FET: frozen‐thawed embryo transfer; GnRHa: gonadotrophin releasing hormone agonist;HCG: human chorionic gonadotrophin; HT: hormone therapy; OR: odds ratio. | ||||||
| GRADE Working Group grades of evidence High quality: We are very confident that the true effect lies close to that of the estimate of the effect Moderate quality: We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different Low quality: Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect Very low quality: We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect | ||||||
1Downgraded one level due to serious risk of bias: study at unclear risk of in most domains of bias (allocation concealment, blinding, selective reporting and other sources of bias). 2Downgraded one level due to serious imprecision: confidence intervals compatible with benefit in either group or with no effect.