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. 2017 Jul 5;2017(7):CD003414. doi: 10.1002/14651858.CD003414.pub3

Azimi Nekoo 2015.

Methods 2‐arm, parallel RCT
2 ART centres
Participants 176 women undergoing FET
Inclusion criteria: infertile women (male factor) aged 20‐37 years who had regular menstrual cycles and had previously undergone IVF or ICSI with the same induction protocol with embryo cryopreservation.
Exclusion criteria: not reported
Baseline characteristics were similar in the 2 groups
Interventions HT (83 women)
Women received oral estradiol valerate 4 mg/d from day 2‐day 5 and 6 mg/d from day 6 to the day of the pregnancy test. In day 13 of cycle, an US examination was performed. After US confirmation of endometrial thickness (8 mm) and no ovarian activity, progesterone suppository 800 mg/d was added. The dose of estradiol was increased to 8 mg/d if endometrial thickness was < 8 mm. 2 or 3 embryos were transferred via transcervical route 48 h after the beginning of progesterone administration. In addition to HT, steroid supplementation was commenced without prior pituitary suppression.
HT plus GnRHa (93 women)
In addition to HT, triptorelin 3.75 mg IM, as a depot GnRHa was administered in the mid‐luteal phase (day 21) of previous cycle.
Outcomes Miscarriage rate per woman
Clinical pregnancy rate per woman
Notes  
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Computer‐generated random sequence
Allocation concealment (selection bias) Unclear risk Not reported
Blinding (performance bias and detection bias) 
 All outcomes Unclear risk Not reported but non‐blinding of outcome assessors may not have affected some of the outcome measures as they were objectively assessed
Incomplete outcome data (attrition bias) 
 All outcomes Low risk All women randomized were included in data analysis
Selective reporting (reporting bias) Unclear risk Insufficient information to make a conclusive judgement
Other bias Low risk Baseline characteristics were similar in the 2 groups