Azimi Nekoo 2015.
Methods | 2‐arm, parallel RCT 2 ART centres |
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Participants | 176 women undergoing FET Inclusion criteria: infertile women (male factor) aged 20‐37 years who had regular menstrual cycles and had previously undergone IVF or ICSI with the same induction protocol with embryo cryopreservation. Exclusion criteria: not reported Baseline characteristics were similar in the 2 groups |
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Interventions |
HT (83 women) Women received oral estradiol valerate 4 mg/d from day 2‐day 5 and 6 mg/d from day 6 to the day of the pregnancy test. In day 13 of cycle, an US examination was performed. After US confirmation of endometrial thickness (8 mm) and no ovarian activity, progesterone suppository 800 mg/d was added. The dose of estradiol was increased to 8 mg/d if endometrial thickness was < 8 mm. 2 or 3 embryos were transferred via transcervical route 48 h after the beginning of progesterone administration. In addition to HT, steroid supplementation was commenced without prior pituitary suppression. HT plus GnRHa (93 women) In addition to HT, triptorelin 3.75 mg IM, as a depot GnRHa was administered in the mid‐luteal phase (day 21) of previous cycle. |
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Outcomes | Miscarriage rate per woman Clinical pregnancy rate per woman |
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Notes | ||
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Low risk | Computer‐generated random sequence |
Allocation concealment (selection bias) | Unclear risk | Not reported |
Blinding (performance bias and detection bias) All outcomes | Unclear risk | Not reported but non‐blinding of outcome assessors may not have affected some of the outcome measures as they were objectively assessed |
Incomplete outcome data (attrition bias) All outcomes | Low risk | All women randomized were included in data analysis |
Selective reporting (reporting bias) | Unclear risk | Insufficient information to make a conclusive judgement |
Other bias | Low risk | Baseline characteristics were similar in the 2 groups |