Eftekhar 2012.
Methods | Single‐centre, 2‐arm, parallel RCT | |
Participants | 130 infertile women who were candidates for FET Inclusion criteria: women who had undergone IVF or ICSI with cryopreservation of excess embryos and fresh cycles with implantation failure. Exclusion criteria: aged > 38 years, BMI > 30 kg/m2, history of endocrine disorders and severe endometriosis Baseline characteristics similar in both groups |
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Interventions |
HT (65 women) All women received estradiol valerate 6 mg/d orally from day 2 of menstrual cycle and progesterone in oil 100 mg IM when the endometrial thickness reached 8 mm ET was performed 3 days after the beginning of progesterone administration. Estradiol and progesterone were continued until the 10th week of gestation HT plus HCG (65 women) As for HT and in addition, women received an HCG 5000 IU injection on the first day of progesterone administration and the day of ET. Embryo thawing was performed 2 days after the first progesterone injection. Embryos were transferred 1 day after thawing using a Labotect catheter (Labotect, Gotting, Germany). |
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Outcomes | Miscarriage Ongoing pregnancy Clinical pregnancy |
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Notes | No outcome data available | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Low risk | Computer‐generated random sequence |
Allocation concealment (selection bias) | Unclear risk | No information reported on allocation concealment |
Blinding (performance bias and detection bias) All outcomes | Unclear risk | No information reported but non‐blinding of outcome assessors may not have affected some of the outcome measures as they were objectively assessed. |
Incomplete outcome data (attrition bias) All outcomes | Unclear risk | No information reported on withdrawals or losses to follow‐up, or both |
Selective reporting (reporting bias) | Low risk | Outcome measures were prespecified in the methods section |
Other bias | Low risk | Baseline characteristics similar in both group |