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. 2017 Jul 5;2017(7):CD003414. doi: 10.1002/14651858.CD003414.pub3

Eftekhar 2012.

Methods Single‐centre, 2‐arm, parallel RCT
Participants 130 infertile women who were candidates for FET
Inclusion criteria: women who had undergone IVF or ICSI with cryopreservation of excess embryos and fresh cycles with implantation failure.
Exclusion criteria: aged > 38 years, BMI > 30 kg/m2, history of endocrine disorders and severe endometriosis
Baseline characteristics similar in both groups
Interventions HT (65 women)
All women received estradiol valerate 6 mg/d orally from day 2 of menstrual cycle and progesterone in oil 100 mg IM when the endometrial thickness reached 8 mm
ET was performed 3 days after the beginning of progesterone administration. Estradiol and progesterone were continued until the 10th week of gestation
HT plus HCG (65 women)
As for HT and in addition, women received an HCG 5000 IU injection on the first day of progesterone administration and the day of ET. Embryo thawing was performed 2 days after the first progesterone injection. Embryos were transferred 1 day after thawing using a Labotect catheter (Labotect, Gotting, Germany).
Outcomes Miscarriage
Ongoing pregnancy
Clinical pregnancy
Notes No outcome data available
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Computer‐generated random sequence
Allocation concealment (selection bias) Unclear risk No information reported on allocation concealment
Blinding (performance bias and detection bias) 
 All outcomes Unclear risk No information reported but non‐blinding of outcome assessors may not have affected some of the outcome measures as they were objectively assessed.
Incomplete outcome data (attrition bias) 
 All outcomes Unclear risk No information reported on withdrawals or losses to follow‐up, or both
Selective reporting (reporting bias) Low risk Outcome measures were prespecified in the methods section
Other bias Low risk Baseline characteristics similar in both group