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. 2017 Jul 5;2017(7):CD003414. doi: 10.1002/14651858.CD003414.pub3

Loh 2001.

Methods Single‐centre, 3‐arm, parallel RCT
Participants 130 women (156 FET cycles)
Baseline characteristics were similar in the 2 groups
Infertility cause: variety of causes
Interventions HT group (44 women (52 cycles))
E2 was used in graduated dose (2 mg‐8 mg) until endometrial thickness was ≥ 8 mm Progesterone pessaries for 2 days before FET. E2 and progesterone continued until day 17 post FET
Clomiphene group (55 women (67 cycles))
Low‐dose clomiphene
HT plus GnRHa group (31 women (37 cycles))
GnRHa then E2 and progesterone (as per HT group)
Outcomes Clinical pregnancy rate per cycle
Endometrial thickness
Notes The study was an abstract; however, the first author provided some study details but it was still not possible to obtain the pregnancy rate per woman; there were multiple cycles per woman and total number of cycles were not equivalent to number of women randomized.
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Method used in generating sequence not reported
Allocation concealment (selection bias) Low risk Allocation was said to have been concealed using sequentially‐numbered, sealed, opaque envelopes
Blinding (performance bias and detection bias) 
 All outcomes Unclear risk Reported that intervention providers were blinded to endometrial preparation; however, participants and outcome assessors were not blinded. Non‐blinding of outcome assessors could affect some of the outcome measures
Incomplete outcome data (attrition bias) 
 All outcomes Unclear risk There were no reports on attrition or reasons for withdrawal
Selective reporting (reporting bias) Unclear risk There was insufficient information to determine whether outcomes were selectively reported
Other bias Unclear risk Insufficient information provided to assess possible sources of other bias