Comparison 1. Antioxidant multivitamin and mineral supplement versus placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Progression to late AMD (neovascular AMD or geographic atrophy)	3	2445	Odds Ratio (Fixed, 95% CI)	0.72 [0.58, 0.90]
2 Progression to neovascular AMD	1		Odds Ratio (Fixed, 95% CI)	Totals not selected
3 Progression to geographic atrophy	1		Odds Ratio (Fixed, 95% CI)	Totals not selected
4 Progression to visual loss (loss of 3 or more lines on logMAR chart)	1		Odds Ratio (Fixed, 95% CI)	Totals not selected
5 Mean visual acuity	5	595	Mean Difference (IV, Fixed, 95% CI)	0.02 [‐0.03, 0.07]
5.1 Mean visual acuity at end of study	1	59	Mean Difference (IV, Fixed, 95% CI)	0.04 [‐0.13, 0.21]
5.2 Change in visual acuity	4	536	Mean Difference (IV, Fixed, 95% CI)	0.02 [‐0.03, 0.07]
6 Quality of life	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected