Binning 2007.

Methods	RCT, DB, single and multiple dose phases, 3 parallel groups Medication administered when baseline pain reached a moderate to severe intensity Pain assessed at 0, 15, 30, 45 mins, then 1, 1.5, 2, 2.5, 3, 4, 5, 6 and 8 hours
Participants	Arthroscopic knee surgery Mean age 38 years N = 94 M = 66, F = 28
Interventions	Naproxen 500 mg, n = 34 Nimesulide 100 mg, n = 29 Placebo, n = 31
Outcomes	PI: 100 mm VAS (and non‐std 5 point scale) PR: std 5 point scale PGE: std 5 point scale Number of participants using rescue medication Number of participants reporting serious adverse events
Notes	Oxford Quality Score: R1, DB2, W1 Period before rescue medication permitted unspecified. Rescue medication: paracetamol 500 mg up to 6 x daily