Malmstrom 2004.

Methods	RCT, BD, single dose, 4 parallel groups Medication administered when baseline pain reached a moderate to severe intensity Pain assessed at 0, 15, 30, 45, 60, 90, 120 mins, then hourly to 8 hours, then at 10, 12, 20 and 24 hours
Participants	Surgical extraction of ≥2 third molars, with 1 impacted Mean age 201 N = 201 M = 97, F = 104
Interventions	Naproxen sodium 550 mg, n = 50 Etoricoxib 120 mg, n = 50 Paracetamol plus codeine 600/60 mg, n = 50 Placebo, n = 50
Outcomes	PI: std 4 point scale PR: std 5 point scale PGE: std 5 point scale Time to use of rescue medication Number of participants using rescue medication Number of participants with any and serious adverse events Number of participants withdrawing due to adverse events
Notes	Oxford Quality Score: R2, DB2, W1 Rescue medication permitted after 1.5 hours. Rescue medication: paracetamol/hydrocodone 500/550 mg