Merck 1997a.

Methods	RCT, DB, single dose, 6 parallel groups Medication administered when baseline pain reached a moderate to severe intensity Pain assessed up to 24 hours
Participants	Surgical extraction of ≥2 third molars Age not given N = 228 M and F (numbers not given)
Interventions	Naproxen sodium 550 mg, n = 39 MK‐0966 7.5 mg, n = 38 MK‐0966 25 mg, n = 38 MK‐0966 50 mg, n =38 MK‐0966 100 mg, n = 38 Placebo, n = 38 (MK‐0966 is rofecoxib)
Outcomes	PI: std 4 point scale PR: std 5 point PR scale Time to use of rescue medication Number of participants using rescue medication Number of participants with any adverse event
Notes	Oxford Quality Score: R1, BD2, W0 No details of rescue medication Currently unpublished