Comeri 1985.

Methods	Randomised, double blind, active control, No placebo group Baseline PI = moderate or severe pain (82.5 mm on a 100 mm VAS) Self assessment at t = 0, 0.5, 1 hr
Participants	N=148 Dipyrone 1 g + pitofenon 0.4 mg + fenpiverine 0.04 mg, n=50 Diclofenac 75 mg, n=48 Indomethacin 50 mg, n= 50
Interventions	Dipyrone 1 g + pitofenon 0.4 mg + fenpiverine 0.04 mg Diclofenac 75 mg Indomethacin 50 mg Single IM dose, 1 hr If the PI had not decreased by 50% of the initial value at 60 mins after the first dose, the patient received a second injection of the same drug in a double blind manner. Any patient not experiencing a decrease of PI after the second dose was removed from the study
Outcomes	PI (VAS 0‐100 mm) PR > 50% at 30mins: Dipyrone=28/50 Diclofencac=38/48 Indomethacin = 34/50
Notes	No AEs were reported by any patient Single dose AEs: 15 patients dropped out: diclofenac (3), indomethacin (6), dipyrone (6) QS=4
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment (selection bias)	Low risk	A ‐ Adequate