Mora‐Durban 1992.

Methods	Randomised, double blind No placebo group Baseline PI = severe pain Self assessment at t = 0, 10, 20, 30, 45, 60 min
Participants	N=51 Dipyrone 2 g + hyoscine 20 mg: n=26 Flurbiprofen 150 mg: n=25
Interventions	Dipyrone 2 g + hyoscine 20 mg Flurbiprofen 150 mg Single IM dose, 1 hr Rescue medication was allowed 20 min after the first dose. 34% of patients on dipyrone and 26.9% on flubiprofen took rescue anlagesia.
Outcomes	PI = nonstandard 5 point categorical scale (0‐4) VAS (0‐100mm) for PI Global rating of treatment effect by the patient and the physician (4 point scale) 20 min SPID: Dipyrone 2 g + hyoscine 20 mg=8.28 Flurbiprofen 150 mg=9.82
Notes	1 patient from the flubiprofen group did not meet the inclusion criteria. Adverse effects: Multiple dose AEs: Number of patients with AEs:19.2% (5 patients) dipyrone; 11.5% (3 patients) flurbiprofen Local pain at injection site: dipyrone 2 g + hyoscine 20 mg (5); flurbiprofen 150 mg (3). QS = 3
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment (selection bias)	Low risk	A ‐ Adequate