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. 2019 Mar 7;4(5):e124687. doi: 10.1172/jci.insight.124687

Figure 6. In vitro proinflammatory activity of supernatant from health- and acne-associated P.

Figure 6

acnesstrains. (A) HaCaT cells were stimulated for 12 hours with supernatant (10 μl) from overnight P. acnes cultures, and cytokines levels were determined by ELISA. (B) Bone marrow–derived macrophages were stimulated for 12 hours with supernatant (10 μl) from overnight P. acnes cultures, and cytokines were measured by ELISA. Data are shown as mean ± SEM (n = 3) and are representative of 3 experiments. Data analysis compared cytokines induced by P. acnes RT4/5 (all 5 strains) versus RT2/6 (all 4 strains) using nonparametric Mann-Whitney U test. P < 0.001, comparing red and green strains.