Figure 3. Lack of proglucagon peptide input reduces insulin secretion in response to both triggering and amplification signals.

Insulin secretion in response to different concentrations of 2.7 mM glucose, 10 mM glucose, 400 μM diazoxide (Dz), or Dz with 30 mM KCl, as indicated from WT (n = 5) or Gcg^null islets (n = 6). Data are shown as mean ± SEM. Data were analyzed by a 2-way ANOVA of the iAUCs or a 2-tailed Student’s t test (inset).