Skip to main content
. 2014 May 19;2014(5):CD009446. doi: 10.1002/14651858.CD009446.pub2

Cornell 1993.

Methods Study type: RCT of body parts
Randomisation method: computerised randomisation
Blinding: double‐blind
Intention‐to‐treat analysis used: yes
Participants Inclusion criteria of the trial
  • Seborrhoeic dermatitis of the scalp


Exclusion criteria of the trial
  • Pregnant and nursing women

  • People with known hypersensitivities to any of the products or their ingredients

  • People with evidence of atrophy


Number of randomised participants: 30 in total
Number of dropouts: 1 (3%)
Sex: 14 males, 16 females
Age (mean): 37.7 years
Country: USA
Interventions Treatment
  • Desonide 0.05% cream, applied to the scalp twice daily for 8 weeks


Comparator/s
  • Hydrocortisone 1.0% cream, applied to the scalp twice daily for 8 weeks

Outcomes
  1. Total number of telangiectasia

Notes 1 of 2 included studies comparing mild steroids with each other. The adverse events rate was calculated from a table
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Computerised randomisation was used
Allocation concealment (selection bias) Unclear risk No information was provided
Similarity of the study groups (selection bias) Unclear risk Bilateral disease severity was not reported separately
Blinding of participants (performance bias) Low risk Colour‐coded side‐labelled tubes were used
Blinding of care providers (performance bias) Unclear risk Whilst the study was reported to be double‐blind, it was not clear who was blinded
Blinding of outcome assessment (detection bias) 
 All outcomes Unclear risk Whilst the study was reported to be double‐blind, it was not clear who was blinded
Incomplete outcome data (attrition bias) 
 All outcomes Low risk The number of dropouts was small
Selective reporting (reporting bias) Low risk No selective reporting bias was identified
Other bias Unclear risk The pharmaceutical industry supported the study, and the corresponding author was affiliated with the pharmaceutical industry