Firooz 2006.

Methods	Study type: individual RCT Randomisation method: computer‐generated randomisation list Blinding: investigator‐blind Intention‐to‐treat analysis used: yes
Participants	Inclusion criteria of the trial Facial seborrhoeic dermatitis Exclusion criteria of the trial Malignant or active viral lesions on the face People who had used antibiotics, immunosuppressive drugs, or phototherapy 1 month before treatment, and any topical therapy suspected to affect facial SeD during the 1 week before the beginning of the study Number of randomised participants: 40 in total (pimecrolimus N = 20, hydrocortisone N = 20) Number of dropouts: 3 (8%) Sex: 28 males, 12 females Age (mean): pimecrolimus arm = 28.65 years, hydrocortisone arm = 37.45 years Country: Iran
Interventions	Treatment Pimecrolimus 1% cream, applied to the face twice daily for 2 weeks Comparator/s Hydrocortisone 1% cream, applied to the face twice daily for 2 weeks
Outcomes	Complete disappearance of disease Severity of pruritus, erythema, and scaling (scales 0 to 3) Adverse events Relapses
Notes	‐
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Randomisation was computer‐generated
Allocation concealment (selection bias)	Unclear risk	This was not reported
Similarity of the study groups (selection bias)	Low risk	There were no statistically significant differences between groups
Blinding of participants (performance bias)	High risk	Only investigators were blinded
Blinding of care providers (performance bias)	Unclear risk	Quote: "investigator blind" This probably refers to outcome assessment
Blinding of outcome assessment (detection bias) All outcomes	Low risk	The investigator was blinded. We assume this refers to outcome assessment
Incomplete outcome data (attrition bias) All outcomes	Low risk	The number of dropouts was acceptable
Selective reporting (reporting bias)	Low risk	Predefined outcomes were reported
Other bias	Unclear risk	The pharmaceutical industry provided ‐ free of charge ‐ the intervention creams