Kousidou 1992.

Methods	Study type: individual RCT Randomisation method: not reported Blinding: double‐blind Intention‐to‐treat analysis used: not reported
Participants	Inclusion criteria of the trial Seborrhoeic dermatitis Exclusion criteria of the trial Not reported Number of randomised participants: 40 in total (hydrocortisone N = 20, ketoconazole N = 20) Number of dropouts: 1 (3%) Sex: 21 males, 19 females Age (mean): 33.7 years Country: Greece
Interventions	Treatment Hydrocortisone 1% cream, applied to the affected areas once daily for 4 weeks Comparator/s Ketoconazole 2% cream, applied to the affected areas once daily for 4 weeks
Outcomes	Erythema score (scale 0 to 9), scaling score (scale 0 to 10), pruritus score (scale 0 to 6), decrease in the number of Pityrosporum ovale colonies, and global evaluation (total improvement, good, fair, poor) Adverse events
Notes	No standard deviations nor exact P values were given in the report. We have approximated the actual numbers from figures
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Quote: "They were randomized"
Allocation concealment (selection bias)	Unclear risk	This was not reported
Similarity of the study groups (selection bias)	Low risk	Quote: "At the start of treatment, erythema, scaling, and pruritus were present in all patients of both groups without any statistically significant difference in the mean scores"
Blinding of participants (performance bias)	Unclear risk	Whilst the study was reported to be double‐blind, it was not clear who was blinded
Blinding of care providers (performance bias)	Unclear risk	Whilst the study was reported to be double‐blind, it was not clear who was blinded
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Whilst the study was reported to be double‐blind, it was not clear who was blinded
Incomplete outcome data (attrition bias) All outcomes	Low risk	The dropout rate was small
Selective reporting (reporting bias)	Low risk	Predefined outcomes were reported
Other bias	Unclear risk	2 authors were affiliated to the pharmaceutical industry