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. 2014 May 19;2014(5):CD009446. doi: 10.1002/14651858.CD009446.pub2

Pari 1998.

Methods Study type: individual RCT
Randomisation method: "stratified blocked random method"
Blinding: double‐blind
Intention‐to‐treat analysis used: at least partly
Participants Inclusion criteria of the trial
  • Seborrhoeic dermatitis of the face and trunk


Exclusion criteria of the trial
  • People on chlorpromazine, cimetidine, alpha‐methyldopa, INAH (isonicotinic acid hydrazide), or steroids

  • Infants

  • People with Parkinsonism or AIDS


Number of randomised participants: 36 in total (clobetasol N = 19, ketoconazole N = 17)
Number of dropouts: 5 (14%)
Sex: not reported
Age: not reported
Country: India
Interventions Treatment
  • Clobetasol 17‐butyrate 0.05% cream, applied to the affected areas (except scalp) twice daily for 4 weeks


Comparator/s
  • Ketoconazole 2% cream, applied to the affected areas (except scalp) twice daily for 4 weeks

Outcomes
  1. Severity score (severity combined with erythema, scaling, and papules)

  2. Itching (scale not reported)

  3. Remission rate

  4. Relapse rate (at the end of 3 months)

  5. Side‐effect profile

Notes Results were not reported separately for face and trunk. Adverse events were not reported
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Quote: "A stratified blocked random method was used to allocate the recruited patients into two groups according to severity"
Allocation concealment (selection bias) Unclear risk This was not reported in detail
Similarity of the study groups (selection bias) Unclear risk This was not reported in detail
Blinding of participants (performance bias) Low risk Quote: "Neither the doctor nor the patient knew"
Blinding of care providers (performance bias) Low risk Quote: "Neither the doctor nor the patient knew"
Blinding of outcome assessment (detection bias) 
 All outcomes Unclear risk The study did not report whether the outcome was assessed by a third party
Incomplete outcome data (attrition bias) 
 All outcomes Low risk The dropout rate was acceptable
Selective reporting (reporting bias) High risk The predefined outcomes included side‐effects, but they were not reported
Other bias Low risk No other bias was identified