DATABASE	Search terms
CENTRAL	1. Kidney Transplantation, MESH term 2. Tacrolimus, MESH 3. (tacrolimus):ti,ab,kw 4. "FK 506" or FK506:ti,ab,kw 5. Cyclosporine, MeSH term 6. (cyclosporin* or ciclosporin*):ti,ab,kw 7. (csa* or neoral* or cya* or restasis or sandimmun*):ti,ab,kw 8. (calcineurin inhibitor*):ti,ab,kw 9. (2 OR 3 OR 4 OR 5 OR 6 OR 7 OR 8) 10. (discontinu* or withdraw* or taper* or spar* or avoid* or minim* or remov* or stop* or reduction* or reduc* or free*):ti,ab,kw 11. (9 AND 10) 12. (1 AND 11)
MEDLINE	1. Kidney Transplantation/ 2. Tacrolimus/ 3. tacrolimus.tw. 4. prograf$.tw. 5. ("FK 506" or FK506).tw. 6. fr‐900506.tw. 7. fujimycin.tw. 8. protopic.tw. 9. Cyclosporine/ 10. cyclosporin$.tw. 11. ciclosporin$.tw. 12. csa.tw. 13. neoral.tw. 14. cya$.tw. 15. sandimmun$.tw. 16. restasis.tw. 17. calcineurin inhibitor$.tw. 18. or/2‐17 19. (discontinu$ or withdraw$ or taper$ or spar$ or avoid$ or minim$ or remov$ or stop$ or reduction or reduc$ or free$).tw. 20. and/18‐19 21. and/1,20
EMBASE	1. Kidney Transplantation/ 2. Tsukubaenolide/ 3. tacrolimus.tw. 4. prograf$.tw. 5. ("FK 506" or FK506).tw. 6. fr‐900506.tw. 7. fujimycin.tw. 8. protopic.tw. 9. Cyclosporin/ 10. cyclosporin$.tw. 11. ciclosporin$.tw. 12. (csa or neoral or cya).tw. 13. (sandimmun$ or restaisi).tw. 14. Calcineurin Inhibitor/ 15. or/2‐14 16. (discontinu$ or withdraw$ or taper$ or spar$ or avoid$ or minim$ or remov$ or stop$ or reduction or reduc$ or free$).tw. 17. and/15‐16 18. and/1,17