Rossini 2007.

Methods	Study design: parallel RCT Study duration: recruitment not reported Duration of follow‐up: 2 years
Participants	Setting: single centre Country: Italy Patients with biopsy‐proven CAN and on treatment with CNI Number: treatment group (6); control group (6) Mean age ± SD (years): not reported Sex (M/F): not reported Exclusion criteria: not reported
Interventions	Treatment group Rapamycin: regimen not reported Control group CNI‐based regimens: regimen not reported
Outcomes	Kidney biopsy at 2 years: record vascular endothelial growth factor expression in the glomerulus, total glomerular area on morphometry Urinary protein SCr
Notes	Abstract‐only publication Funding source: not reported
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Study was described as randomised, method of randomisation was not reported
Allocation concealment (selection bias)	Unclear risk	Insufficient information to permit judgement
Blinding of participants and personnel (performance bias) All outcomes	High risk	Open‐label study
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Insufficient information to permit judgement
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Biopsy documented at 2 years for all 12 patients
Selective reporting (reporting bias)	High risk	All prespecified outcomes noted; no full text publication by 2017
Other bias	Unclear risk	Insufficient information to permit judgement