Stallone 2003.

Methods	Study design: parallel RCT Study duration: recruitment not reported Duration of follow‐up: 12 months
Participants	Setting: single centre Country: Italy Consecutive kidney transplant recipients from cadaveric donors Number: treatment group (20); control group (20) Mean age ± SD (years): treatment group (40 ± 10); control group (47 ± 5) Sex (M/F): not reported Exclusion criteria: not reported
Interventions	Treatment group CsA withdrawal SRL trough levels: 10 to 15 ng/mL PRED Control group CsA trough levels: 150 to 250 ng/mL SRL: 2 mg/d PRED Both groups (to 3 months) PRED: 200 mg/d then tapered to 25 mg (day 8) and to 5 mg (month 6) CsA trough levels: 150 to 250 ng/mL SRL: 2 mg/d
Outcomes	Graft biopsy at 12 months for chronic changes Incidence of DGF AR Graft function CrCl
Notes	Funding source: not reported
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Study was described as randomised, method of randomisation was not reported
Allocation concealment (selection bias)	Unclear risk	Insufficient information to permit judgement
Blinding of participants and personnel (performance bias) All outcomes	High risk	Open‐label study
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	No blinding of outcome assessment
Incomplete outcome data (attrition bias) All outcomes	Low risk	All patients accounted for
Selective reporting (reporting bias)	Low risk	All prespecified outcomes reported
Other bias	Low risk	Insufficient information to permit judgement