Summary of findings for the main comparison. 75 g OGTT versus 100 g OGTT for diagnosing GDM to improve maternal and infant health.
75 g oral glucose tolerance test (OGTT) versus 100 g OGTT for diagnosing gestational diabetes mellitus (GDM) to improve maternal and infant health | ||||||
Patient or population: pregnant women at low or high risk of gestational diabetes
Settings: 1 study, Nigeria
Intervention: 75 g OGTT Comparison: 100 g OGTT | ||||||
Outcomes | Illustrative comparative risks* (95% CI) | Relative effect (95% CI) | Number of participants (studies) | Quality of the evidence (GRADE) | Comments | |
Assumed risk | Corresponding risk | |||||
100 g OGTT | 75 g OGTT | |||||
Diagnosis of gestational diabetes | Study population | RR 2.55 (0.96 to 6.75) | 248 (1 study) | ⊕⊝⊝⊝ Very lowa,b | Women who received the 75 g OGTT test were 2.55 times more likely to test positive for gestational diabetes. | |
45 per 1000 | 116 per 1000 (44 to 307) | |||||
Caesarean section | See comment | See comment | Not estimable | 0 (0) | See comment | None of the included studies reported this outcome. |
Macrosomia > 4.5 kg or as defined in trial | See comment | See comment | Not estimable | 0 (0) | See comment | None of the included studies reported this outcome. |
Long‐term type 2 diabetes maternal | See comment | See comment | Not estimable | 0 (0) | See comment | None of the included studies reported this outcome. |
Long‐term type 2 diabetes infant | See comment | See comment | Not estimable | 0 (0) | See comment | None of the included studies reported this outcome. |
Economic costs | See comment | See comment | Not estimable | 0 (0) | See comment | None of the included studies reported this outcome. |
*The basis for the assumed risk (e.g. median control group risk across studies) is the risk. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: Confidence interval; RR: Risk ratio. | ||||||
GRADE Working Group grades of evidence. High quality: Further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: We are very uncertain about the estimate. |
aOne study with design limitations (‐1). bWide confidence intervals crossing the line of no effect, few events and small sample size.