1 Overall survival |
10 |
2135 |
Hazard Ratio (Fixed, 95% CI) |
0.87 [0.80, 0.95] |
1.1 Substitutive comparisons |
6 |
826 |
Hazard Ratio (Fixed, 95% CI) |
0.87 [0.75, 1.00] |
1.2 Additive comparisons |
3 |
500 |
Hazard Ratio (Fixed, 95% CI) |
0.88 [0.76, 1.03] |
1.3 Other comparisons |
2 |
809 |
Hazard Ratio (Fixed, 95% CI) |
0.87 [0.76, 1.00] |
2 Tumour response |
10 |
1266 |
Odds Ratio (M‐H, Random, 95% CI) |
1.72 [1.24, 2.40] |
2.1 Substitutive comparisons |
6 |
756 |
Odds Ratio (M‐H, Random, 95% CI) |
1.53 [0.93, 2.50] |
2.2 Additive comparisons |
3 |
345 |
Odds Ratio (M‐H, Random, 95% CI) |
2.18 [1.25, 3.80] |
2.3 Other Comparisons |
2 |
165 |
Odds Ratio (M‐H, Random, 95% CI) |
1.87 [0.89, 3.91] |
3 Progression‐free survival |
7 |
1640 |
Hazard Ratio (Fixed, 95% CI) |
0.76 [0.69, 0.84] |
3.1 Substitutive comparison |
5 |
741 |
Hazard Ratio (Fixed, 95% CI) |
0.85 [0.72, 1.00] |
3.2 Additive comparisons |
1 |
90 |
Hazard Ratio (Fixed, 95% CI) |
0.51 [0.33, 0.77] |
3.3 Other comparisons |
2 |
809 |
Hazard Ratio (Fixed, 95% CI) |
0.74 [0.66, 0.84] |
4 Treatment‐related death |
9 |
1979 |
Odds Ratio (M‐H, Random, 95% CI) |
0.88 [0.23, 3.32] |
5 Treatment discontinuation due to toxicity |
9 |
1979 |
Odds Ratio (M‐H, Random, 95% CI) |
1.00 [0.46, 2.20] |